[HTML][HTML] Alteration of cell cycle-dependent histone phosphorylations by okadaic acid: induction of mitosis-specific H3 phosphorylation and chromatin condensation in …
K Ajiro, K Yoda, K Utsumi, Y Nishikawa - Journal of Biological Chemistry, 1996 - ASBMB
Effects of okadaic acid (OA), a protein phosphatase inhibitor, on chromatin structure and
phosphorylation of histones were examined using HeLa and N18 cells. The chromatin
condensation in HeLa cells was mild and resemble prometaphase nuclei, while the
condensation in N18 cells was extensive and chromatin became a compact body. H2A in
HeLa cells was extensively and consistently phosphorylated at the same site throughout the
cell cycle, and H3 was demonstrated to be phosphorylated at the mitosis-specific site Ser 10 …
phosphorylation of histones were examined using HeLa and N18 cells. The chromatin
condensation in HeLa cells was mild and resemble prometaphase nuclei, while the
condensation in N18 cells was extensive and chromatin became a compact body. H2A in
HeLa cells was extensively and consistently phosphorylated at the same site throughout the
cell cycle, and H3 was demonstrated to be phosphorylated at the mitosis-specific site Ser 10 …