It is well known that the serum concentration of some hormones change by orders of
magnitude multiple times within each day. Luteinizing hormone (LH), growth hormone (GH),
prolactin (PRL), thyrotropin (TSH), and adrenocorticotropic hormone (ACTH) are examples
of hormones that exhibit large, short duration fluctuations in concentration. The temporal
variation in serum hormone concentration is believed to be a significant portion of the
signaling pathway by which endocrine glands communicate with remote target organs …