[HTML][HTML] Nitric oxide regulation of gene transcription via soluble guanylate cyclase and type I cGMP-dependent protein kinase
SD Idriss, T Gudi, DE Casteel, VG Kharitonov… - Journal of Biological …, 1999 - ASBMB
Nitric oxide (NO) regulates the expression of multiple genes but in most cases its precise
mechanism of action is unclear. We used baby hamster kidney (BHK) cells, which have very
low soluble guanylate cyclase and cGMP-dependent protein kinase (G-kinase) activity, and
CS-54 arterial smooth muscle cells, which express these two enzymes, to study NO
regulation of the human fos promoter. The NO-releasing agent Deta-NONOate (ethanamine-
2, 2′-(hydroxynitrosohydrazone) bis-) had no effect on a chloramphenicol acetyltransferase …
mechanism of action is unclear. We used baby hamster kidney (BHK) cells, which have very
low soluble guanylate cyclase and cGMP-dependent protein kinase (G-kinase) activity, and
CS-54 arterial smooth muscle cells, which express these two enzymes, to study NO
regulation of the human fos promoter. The NO-releasing agent Deta-NONOate (ethanamine-
2, 2′-(hydroxynitrosohydrazone) bis-) had no effect on a chloramphenicol acetyltransferase …