PKB/AKT: functional insights from genetic models

MP Scheid, JR Woodgett - Nature reviews Molecular cell biology, 2001 - nature.com
Nature reviews Molecular cell biology, 2001nature.com
Since its discovery 10 years ago, the potential functions of protein kinase B (PKB)/AKT have
been catalogued with increasing efficiency. The physiological relevance of some of the
proposed mechanisms by which PKB/AKT mediates many of its effects has been
questioned, and recent work using new reagents and approaches has revealed some
cracks in our understanding of this important molecule, and also hinted that these effects
may involve other players.
Abstract
Since its discovery 10 years ago, the potential functions of protein kinase B (PKB)/AKT have been catalogued with increasing efficiency. The physiological relevance of some of the proposed mechanisms by which PKB/AKT mediates many of its effects has been questioned, and recent work using new reagents and approaches has revealed some cracks in our understanding of this important molecule, and also hinted that these effects may involve other players.
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