Few studies have examined the role of the microvasculature in progressive renal disease. It
was hypothesized that impaired angiogenesis might occur in the diseased kidney and could
contribute to renal scarring. Progressive renal disease was induced in rats by 5/6 renal
ablation and those rats were compared with sham-operated control animals at multiple time
points, for examination of changes in the microvasculature and the expression of angiogenic
factors. An early angiogenic response was documented in remnant kidneys, with increases …