Thyrocalcitonin: inhibitor of bone resorption in tissue culture
J Friedman, LG Raisz - Science, 1965 - science.org
J Friedman, LG Raisz
Science, 1965•science.org(pg) (ag) Thyrocalcitonin: Inhibitor of Page 1 Table 1. Effects of hypophysectomy and ACTH on
theadrenaline-forming enzyme in theadrenal * gland. Rats were hypophysectomized 17 days
prior to assay. Some animals were given ACTH, 4 units subcutaneously per day, for 6 days
before the assay. Each group contained 6 to 12 animals. PNMT (nmole) Adrenaline Weight Per
Percentage (mg/pair) Per Per pair catecholpair gram (pg) amine* Control 61.3±1.9t 5.86±.50t
96.0±8.01 30.1±1.1t 91.8±40.3t Hypophysectomy 22.740.7 1.424 .12 62.0± 22.2± 1.1 80.2±0.7 …
theadrenaline-forming enzyme in theadrenal * gland. Rats were hypophysectomized 17 days
prior to assay. Some animals were given ACTH, 4 units subcutaneously per day, for 6 days
before the assay. Each group contained 6 to 12 animals. PNMT (nmole) Adrenaline Weight Per
Percentage (mg/pair) Per Per pair catecholpair gram (pg) amine* Control 61.3±1.9t 5.86±.50t
96.0±8.01 30.1±1.1t 91.8±40.3t Hypophysectomy 22.740.7 1.424 .12 62.0± 22.2± 1.1 80.2±0.7 …
A partially purified protein from thyroid glands of rats inhibits release of calcium from long bones of embryo rats in tissue culture. Inhibition was more easily detected when resorption of bone was stimulated by parathyroid hormone.
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