[CITATION][C] 5-Hydroxytryptophan Uptake by Dog Thyroid 'C' Cells, and its Possible Significance in Polypeptide Hormone Production
AGE Pearse - Nature, 1966 - nature.com
AGE Pearse
Nature, 1966•nature.comTHE C cells of the dog thyroid have been shown to be identical with the argyrophil
parafollicular cells described in that animal by Nonidez***. As indicated in earlier papers**,
these cells arc sensitive to physiological changes in serum calcium-levels and they respond
to high calciumlevels, of short duration, by discharging their contents. It has been postulated
that the secretion product of the C cells is calcitonin (thyrocalcitonin)–the calciumregulating
hormone in the serum?**. Evidence was recently provided by Hargis et al., who used an …
parafollicular cells described in that animal by Nonidez***. As indicated in earlier papers**,
these cells arc sensitive to physiological changes in serum calcium-levels and they respond
to high calciumlevels, of short duration, by discharging their contents. It has been postulated
that the secretion product of the C cells is calcitonin (thyrocalcitonin)–the calciumregulating
hormone in the serum?**. Evidence was recently provided by Hargis et al., who used an …
THE C cells of the dog thyroid have been shown to be identical with the argyrophil parafollicular cells described in that animal by Nonidez***. As indicated in earlier papers**, these cells arc sensitive to physiological changes in serum calcium-levels and they respond to high calciumlevels, of short duration, by discharging their contents. It has been postulated that the secretion product of the
C cells is calcitonin (thyrocalcitonin)–the calciumregulating hormone in the serum?**. Evidence was recently provided by Hargis et al., who used an immunofluorescent technique on pig thyroid, that thyrocalcitonin “must be synthesized or stored in the same cells that elaborate thyroglobulin”. These are indisputably the acinar (“A”) cells. Notwithstanding,
nature.com