Control of osteoclastogenesis and bone resorption by members of the TNF family of receptors and ligands
MC Horowitz, Y Xi, K Wilson, MA Kacena - Cytokine & growth factor reviews, 2001 - Elsevier
Skeletal mass is maintained by a balance between cells which resorb bone (osteoclasts)
and cells which form bone (osteoblasts). Bone development and growth is an on-going, life-
long process. Bone is formed during embryonic life, grows rapidly through childhood, and
peaks around 20 years of age (formation exceeds resorption). For humans the skeleton then
enters a long period, approximately 40 years, when bone mass remains relatively stable.
Skeletal turnover continues but the net effect of resorption and formation on bone mass is …
and cells which form bone (osteoblasts). Bone development and growth is an on-going, life-
long process. Bone is formed during embryonic life, grows rapidly through childhood, and
peaks around 20 years of age (formation exceeds resorption). For humans the skeleton then
enters a long period, approximately 40 years, when bone mass remains relatively stable.
Skeletal turnover continues but the net effect of resorption and formation on bone mass is …