A kinase in the life of the β cell
D Accili - The Journal of Clinical Investigation, 2001 - jci.org
D Accili
The Journal of Clinical Investigation, 2001•jci.orgPancreatic β cells synthesize, store, and secrete insulin in response to appropriate
environmental cues. The classic paradigm, as originally proposed by Matschinsky (1), holds
that the products of glucose metabolism in β cells control insulin production and release. In
recent years, this view has been broadened to include signaling by receptor tyrosine
kinases as part of the β cell sensing mechanism, impinging on such diverse functions as
insulin release and cellular proliferation (2).
environmental cues. The classic paradigm, as originally proposed by Matschinsky (1), holds
that the products of glucose metabolism in β cells control insulin production and release. In
recent years, this view has been broadened to include signaling by receptor tyrosine
kinases as part of the β cell sensing mechanism, impinging on such diverse functions as
insulin release and cellular proliferation (2).
Pancreatic β cells synthesize, store, and secrete insulin in response to appropriate environmental cues. The classic paradigm, as originally proposed by Matschinsky (1), holds that the products of glucose metabolism in β cells control insulin production and release. In recent years, this view has been broadened to include signaling by receptor tyrosine kinases as part of the β cell sensing mechanism, impinging on such diverse functions as insulin release and cellular proliferation (2).
The Journal of Clinical Investigation