[HTML][HTML] A kinase in the life of the β cell

D Accili - The Journal of Clinical Investigation, 2001 - Am Soc Clin Investig
D Accili
The Journal of Clinical Investigation, 2001Am Soc Clin Investig
Pancreatic β cells synthesize, store, and secrete insulin in response to appropriate
environmental cues. The classic paradigm, as originally proposed by Matschinsky (1), holds
that the products of glucose metabolism in β cells control insulin production and release. In
recent years, this view has been broadened to include signaling by receptor tyrosine
kinases as part of the β cell sensing mechanism, impinging on such diverse functions as
insulin release and cellular proliferation (2).
Pancreatic β cells synthesize, store, and secrete insulin in response to appropriate environmental cues. The classic paradigm, as originally proposed by Matschinsky (1), holds that the products of glucose metabolism in β cells control insulin production and release. In recent years, this view has been broadened to include signaling by receptor tyrosine kinases as part of the β cell sensing mechanism, impinging on such diverse functions as insulin release and cellular proliferation (2).
The Journal of Clinical Investigation