[HTML][HTML] Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion
M Brissova, M Shiota, WE Nicholson, M Gannon… - Journal of Biological …, 2002 - ASBMB
Complete lack of transcription factor PDX-1 leads to pancreatic agenesis, whereas
heterozygosity for PDX-1 mutations has been recently noted in some individuals with
maturity-onset diabetes of the young (MODY) and in some individuals with type 2 diabetes.
To determine how alterations in PDX-1 affect islet function, we examined insulin secretion
and islet physiology in mice with one PDX-1 allele inactivated. PDX-1+/− mice had a normal
fasting blood glucose and pancreatic insulin content but had impaired glucose tolerance …
heterozygosity for PDX-1 mutations has been recently noted in some individuals with
maturity-onset diabetes of the young (MODY) and in some individuals with type 2 diabetes.
To determine how alterations in PDX-1 affect islet function, we examined insulin secretion
and islet physiology in mice with one PDX-1 allele inactivated. PDX-1+/− mice had a normal
fasting blood glucose and pancreatic insulin content but had impaired glucose tolerance …