[HTML][HTML] Hepatitis B virus X protein inhibits transforming growth factor-β-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway
WL Shih, ML Kuo, SE Chuang, AL Cheng… - Journal of Biological …, 2000 - ASBMB
Transforming growth factor-β (TGF-β) is a potent inducer of apoptosis in Hep 3B cells. This
work investigated how hepatitis B virus X protein (HBx) affects TGF-β-induced apoptosis.
Trypan blue exclusion and colony formation assays revealed that HBx increased the ID 50
toward TGF-β. In the presence of HBx, TGF-β-induced DNA laddering was decreased,
indicating that HBx had the ability to block TGF-β-induced apoptosis. Furthermore, HBx did
not alter the expression levels of type I and type II TGF-β receptors. HBx did not affect TGF-β …
work investigated how hepatitis B virus X protein (HBx) affects TGF-β-induced apoptosis.
Trypan blue exclusion and colony formation assays revealed that HBx increased the ID 50
toward TGF-β. In the presence of HBx, TGF-β-induced DNA laddering was decreased,
indicating that HBx had the ability to block TGF-β-induced apoptosis. Furthermore, HBx did
not alter the expression levels of type I and type II TGF-β receptors. HBx did not affect TGF-β …