The hepatitis B virus X protein (HBx) induces a migratory phenotype in a CD44-dependent manner: possible role of HBx in invasion and metastasis
E Lara-Pezzi, JM Serrador, MC Montoya, D Zamora… - Hepatology, 2001 - Elsevier
The hepatitis B virus X protein (HBx) of the hepatitis B virus (HBV) has been involved in the
development of hepatocellular carcinoma (HCC). However, its possible contribution to the
metastatic spreading of liver tumors has not been explored so far. We report here the ability
of HBx to enhance cell motility, both alone and in synergy with growth factors, and to induce
a migratory phenotype in transformed cells. HBx altered the cellular morphology by inducing
the formation of pseudopodial protrusions and cytoskeletal rearrangements, which was …
development of hepatocellular carcinoma (HCC). However, its possible contribution to the
metastatic spreading of liver tumors has not been explored so far. We report here the ability
of HBx to enhance cell motility, both alone and in synergy with growth factors, and to induce
a migratory phenotype in transformed cells. HBx altered the cellular morphology by inducing
the formation of pseudopodial protrusions and cytoskeletal rearrangements, which was …