Renal interstitial fibrosis is reduced in angiotensin II type 1a receptor-deficient mice
M Satoh, N Kashihara, Y Yamasaki… - Journal of the …, 2001 - journals.lww.com
Unilateral ureteral obstruction (UUO) results in tubulointerstitial fibrosis of the affected kidney
by stimulating the renin-angiotensin system. This study established a UUO model in
angiotensin type 1a receptor (AT1a) deficient (mutant) mice to elucidate the role of
angiotensin II through AT1a on the fibrosis of the obstructed kidney (OBK). The relative
volume of the tubulointerstitium was measured by an image analyzer; deposition of collagen
types III and IV and monocyte/macrophage infiltration were histologically examined using …
by stimulating the renin-angiotensin system. This study established a UUO model in
angiotensin type 1a receptor (AT1a) deficient (mutant) mice to elucidate the role of
angiotensin II through AT1a on the fibrosis of the obstructed kidney (OBK). The relative
volume of the tubulointerstitium was measured by an image analyzer; deposition of collagen
types III and IV and monocyte/macrophage infiltration were histologically examined using …