CFTR gene and male fertility.
PY Wong - Molecular human reproduction, 1998 - academic.oup.com
PY Wong
Molecular human reproduction, 1998•academic.oup.comSecretion of electrolytes and water by the epididymal epithelium is important in the formation
an optimal fluid environment for sperm maturation and transport. This process is disrupted in
the genetic disease cystic fibrosis caused by mutation of the cystic fibrosis transmemebrane
conductance regulator (CFTR) gene. Recent findings of CFTR gene mutations in healthy
men with congenital bilateral absence of the vas deferens or poor sperm quality may
indicate that CFTR gene mutations have a far-reaching effect on human reproduction.
an optimal fluid environment for sperm maturation and transport. This process is disrupted in
the genetic disease cystic fibrosis caused by mutation of the cystic fibrosis transmemebrane
conductance regulator (CFTR) gene. Recent findings of CFTR gene mutations in healthy
men with congenital bilateral absence of the vas deferens or poor sperm quality may
indicate that CFTR gene mutations have a far-reaching effect on human reproduction.
Abstract
Secretion of electrolytes and water by the epididymal epithelium is important in the formation an optimal fluid environment for sperm maturation and transport. This process is disrupted in the genetic disease cystic fibrosis caused by mutation of the cystic fibrosis transmemebrane conductance regulator (CFTR) gene. Recent findings of CFTR gene mutations in healthy men with congenital bilateral absence of the vas deferens or poor sperm quality may indicate that CFTR gene mutations have a far-reaching effect on human reproduction.
Oxford University Press