Comparative study of available medical therapy for hypercalcemia of malignancy
GR Mundy, R Wilkinson, DA Heath - The American journal of medicine, 1983 - Elsevier
The relative efficacy of five drugs in the treatment of hypercalcemia of malignancy was
assessed in a randomized study. The drugs were oral phosphate, mithramycin,
glucocorticoids, indomethacin, and ethane-1-hydroxy-1, 1-diphosphonate (EHDP). No
single agent was universally effective. Oral phosphate and mithramycin were the most
efficacious, each producing a decrease in serum calcium concentrations in four of five
patients, although there were serious disadvantages with the use of each. Glucocorticoids …
assessed in a randomized study. The drugs were oral phosphate, mithramycin,
glucocorticoids, indomethacin, and ethane-1-hydroxy-1, 1-diphosphonate (EHDP). No
single agent was universally effective. Oral phosphate and mithramycin were the most
efficacious, each producing a decrease in serum calcium concentrations in four of five
patients, although there were serious disadvantages with the use of each. Glucocorticoids …
