Parathyroid hormone related peptide can function as an autocrine growth factor in human renal cell carcinoma
PBJ Burton, C Moniz, DE Knight - Biochemical and biophysical research …, 1990 - Elsevier
PBJ Burton, C Moniz, DE Knight
Biochemical and biophysical research communications, 1990•ElsevierParathyroid hormone related peptide (PTHrP) has been implicated in the cause of the
hypercalcemia associated with a number of malignant tumours. The data presented here
suggests that PTHrP (in addition to its known role of mediating hypercalcemia) may be
involved in the autocrine regulation of growth of some tumours. Polyclonal PTHrP antiserum
almost totally inhibited the growth of a human renal cell carcinoma cell line, known to
secrete PTHrP, in vitro and growth was significantly inhibited by the competitive PTH …
hypercalcemia associated with a number of malignant tumours. The data presented here
suggests that PTHrP (in addition to its known role of mediating hypercalcemia) may be
involved in the autocrine regulation of growth of some tumours. Polyclonal PTHrP antiserum
almost totally inhibited the growth of a human renal cell carcinoma cell line, known to
secrete PTHrP, in vitro and growth was significantly inhibited by the competitive PTH …
Abstract
Parathyroid hormone related peptide (PTHrP) has been implicated in the cause of the hypercalcemia associated with a number of malignant tumours. The data presented here suggests that PTHrP (in addition to its known role of mediating hypercalcemia) may be involved in the autocrine regulation of growth of some tumours. Polyclonal PTHrP antiserum almost totally inhibited the growth of a human renal cell carcinoma cell line, known to secrete PTHrP, in vitro and growth was significantly inhibited by the competitive PTH antagonist PTH (3–34)NH2.
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