Critical Involvement of Interferon γ in the Pathogenesis of T–Cell Activation–Associated Hepatitis and Regulatory Mechanisms of Interleukin–6 for the Manifestations of …
H Mizuhara, M Uno, N Seki, M Yamashita… - Hepatology, 1996 - journals.lww.com
A single intravenous injection of concanavalin A (Con A) induces T–cell activation and an
acute hepatitis in mice. This study investigated the role of interferon γ (IFN–γ) in the
pathogenesis of this hepatitis model. Striking increases in the plasma levels of various
cytokines, including tumor necrosis factor (TNF), interleukin–2 (IL–2), and IFN–γ, were
detected before the increase in plasma aminotransferase levels induced by Con A injection.
TNF levels peaked within 2 hours, whereas IFN–γ levels peaked at 6 hours after Con A …
acute hepatitis in mice. This study investigated the role of interferon γ (IFN–γ) in the
pathogenesis of this hepatitis model. Striking increases in the plasma levels of various
cytokines, including tumor necrosis factor (TNF), interleukin–2 (IL–2), and IFN–γ, were
detected before the increase in plasma aminotransferase levels induced by Con A injection.
TNF levels peaked within 2 hours, whereas IFN–γ levels peaked at 6 hours after Con A …