[HTML][HTML] Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats
KY Trinh, RM O'Doherty, P Anderson, AJ Lange… - Journal of Biological …, 1998 - ASBMB
The terminal step in hepatic gluconeogenesis is catalyzed by glucose-6-phosphatase, an
enzyme activity residing in the endoplasmic reticulum and consisting of a catalytic subunit
(glucose-6-phosphatase (G6Pase)) and putative accessory transport proteins. We show that
Zucker diabetic fatty rats (fa/fa), which are known to exhibit impaired suppression of hepatic
glucose output, have 2.4-fold more glucose-6-phosphatase activity in liver than lean
controls. To define the potential contribution of increased hepatic G6Pase to development of …
enzyme activity residing in the endoplasmic reticulum and consisting of a catalytic subunit
(glucose-6-phosphatase (G6Pase)) and putative accessory transport proteins. We show that
Zucker diabetic fatty rats (fa/fa), which are known to exhibit impaired suppression of hepatic
glucose output, have 2.4-fold more glucose-6-phosphatase activity in liver than lean
controls. To define the potential contribution of increased hepatic G6Pase to development of …