Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
D Levitan, I Greenwald - Nature, 1995 - nature.com
D Levitan, I Greenwald
Nature, 1995•nature.comAbstract THE lin-12 and glp-1 genes of Caenorhabditis elegans are members of the lin-
12/Notch family of receptors for intercellular signals that specify cell fate1, 2. By screening for
suppressors of a lin-12 gain-of-function mutation, we identified a new gene, sel-12, which
appears to function in receiving cells to facilitate signalling mediated by lin-12 and glp-1.
The sel-12 gene encodes a protein with multiple transmembrane domains, and is similar to
S182, which has been implicated in early-onset familial Alzheimer's disease3. The high …
12/Notch family of receptors for intercellular signals that specify cell fate1, 2. By screening for
suppressors of a lin-12 gain-of-function mutation, we identified a new gene, sel-12, which
appears to function in receiving cells to facilitate signalling mediated by lin-12 and glp-1.
The sel-12 gene encodes a protein with multiple transmembrane domains, and is similar to
S182, which has been implicated in early-onset familial Alzheimer's disease3. The high …
Abstract
THE lin-12 and glp-1 genes of Caenorhabditis elegans are members of the lin-12 / Notch family of receptors for intercellular signals that specify cell fate1,2. By screening for suppressors of a lin-12 gain-of-function mutation, we identified a new gene, sel-12, which appears to function in receiving cells to facilitate signalling mediated by lin-12 and glp-1. The sel-12 gene encodes a protein with multiple transmembrane domains, and is similar to S182, which has been implicated in early-onset familial Alzheimer's disease3. The high degree of sequence conservation suggests that the function of the SEL-12 and S182 proteins may also be conserved.
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