[HTML][HTML] Marked reduction in bile acid synthesis in cholesterol 7α-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to …

M Schwarz, DW Russell, JM Dietschy, SD Turley - Journal of lipid research, 1998 - ASBMB
These studies used mice that were deficient in cholesterol 7α-hydroxylase to determine the
effects of reduced bile acid synthesis on cholesterol homeostasis. In mice lacking this
enzyme, bile acid synthesis was reduced from 8.3 to 3.4 μmol/day per 100 g body weight,
the intestinal bile acid pool was decreased from 62.5 to 13.2 μmol/100 g bw, and the
proportion of hyodeoxycholate, relative to cholate, in this pool was significantly increased.
Associated with these changes, intestinal cholesterol absorption decreased from 37% to< …