Cellular response to double‐stranded RNA

DS Haines, KI Strauss… - Journal of cellular …, 1991 - Wiley Online Library
DS Haines, KI Strauss, DH Gillespie
Journal of cellular biochemistry, 1991Wiley Online Library
The study of double‐stranded RNA (dsRNA) encompasses a variety of fields. Basic research
in this area has contributed to a greater mechanistic understanding of gene induction, tumor
cell growth arrest, the establishment of antiviral states, and immunomodulation. Because of
the possible clinical value of these molecules, physicians are now exploring the use of
synthetic dsRNA to treat patients with cancer, HIV‐1 disease, and immune dysfunction.
Continued studies of the mechanisms of action of dsRNA are likely to suggest an even wider …
Abstract
The study of double‐stranded RNA (dsRNA) encompasses a variety of fields. Basic research in this area has contributed to a greater mechanistic understanding of gene induction, tumor cell growth arrest, the establishment of antiviral states, and immunomodulation. Because of the possible clinical value of these molecules, physicians are now exploring the use of synthetic dsRNA to treat patients with cancer, HIV‐1 disease, and immune dysfunction. Continued studies of the mechanisms of action of dsRNA are likely to suggest an even wider scope of clinical applications.
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