The discovery of MHC restriction
RM Zinkernagel, PC Doherty - Immunology today, 1997 - cell.com
RM Zinkernagel, PC Doherty
Immunology today, 1997•cell.comThe chance discovery 20 years ago that virus-specific cytotoxic T lymphocytes recognized
antigen together with major histocompatibility complex (MHC) class I glycoproteins was the
key to understanding immune surveillance of self. The altered-self hypothesis biological
basis for alloreactivity. MHC polymorphism and immune response (Ir) gene effects. Here,
Nobel Laureates Rolf Zinkernagel restriction∗∗ This Feature article celebrating the work of
Rolf Zinkernagel and Peter Doherty was commissioned by Howard Goodman..
antigen together with major histocompatibility complex (MHC) class I glycoproteins was the
key to understanding immune surveillance of self. The altered-self hypothesis biological
basis for alloreactivity. MHC polymorphism and immune response (Ir) gene effects. Here,
Nobel Laureates Rolf Zinkernagel restriction∗∗ This Feature article celebrating the work of
Rolf Zinkernagel and Peter Doherty was commissioned by Howard Goodman..
Abstract
The chance discovery 20 years ago that virus-specific cytotoxic T lymphocytes recognized antigen together with major histocompatibility complex (MHC) class I glycoproteins was the key to understanding immune surveillance of self. The altered-self hypothesis biological basis for alloreactivity. MHC polymorphism and immune response (Ir) gene effects. Here, Nobel Laureates Rolf Zinkernagel restriction∗∗This Feature article celebrating the work of Rolf Zinkernagel and Peter Doherty was commissioned by Howard Goodman..
cell.com