Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms

VP Skulachev - Molecular aspects of medicine, 1999 - Elsevier
The review summarizes the present state of our knowledge concerning alternative functions
of mitochondria, namely energy conservation in forms of protonic potential and ATP,
thermoregulatory energy dissipation as heat, production of useful substances,
decomposition of harmful substances, control of cellular processes. The recent progress in
understanding of some mitochondrion-linked pathologies is described. The role of reactive
oxygen species in these processes is stressed. Possible mechanisms of programmed death …