Regulation of MMP-9 production by human corneal epithelial cells
DQ Li, BL Lokeshwar, A Solomon, D Monroy, Z Ji… - Experimental eye …, 2001 - Elsevier
The matrix metalloproteinases, MMP-2 and MMP-9, are known to be critical extracellular-
remodeling enzymes in wound healing and other diseases of the ocular surface. This study
investigated the regulation of MMP-2 and MMP-9 in human corneal epithelial cells by growth
factors and pro-inflammatory cytokines (IL-1β and TNF-α) they are exposed to, and by
doxycycline, a medication used to treat ocular surface disease. Primary human corneal
epithelial cell cultures were treated with one of the following cytokines (IL-1α, IL-1β, IL-6, IL …
remodeling enzymes in wound healing and other diseases of the ocular surface. This study
investigated the regulation of MMP-2 and MMP-9 in human corneal epithelial cells by growth
factors and pro-inflammatory cytokines (IL-1β and TNF-α) they are exposed to, and by
doxycycline, a medication used to treat ocular surface disease. Primary human corneal
epithelial cell cultures were treated with one of the following cytokines (IL-1α, IL-1β, IL-6, IL …