The N-end rule: functions, mysteries, uses.
A Varshavsky - Proceedings of the National Academy of …, 1996 - National Acad Sciences
A Varshavsky
Proceedings of the National Academy of Sciences, 1996•National Acad SciencesThe N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue.
Similar but distinct versions of the N-end rule operate in all organisms examined, from
mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the
ubiquitin system. I discuss the mechanisms and functions of this pathway, and consider its
applications.
Similar but distinct versions of the N-end rule operate in all organisms examined, from
mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the
ubiquitin system. I discuss the mechanisms and functions of this pathway, and consider its
applications.
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. I discuss the mechanisms and functions of this pathway, and consider its applications.
National Acad Sciences