Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model
SN Chatfield, K Strahan, D Pickard, IG Charles… - Microbial …, 1992 - Elsevier
Derivatives of the mouse-virulent Salmonella typhimurium strain SL1344 were constructed
harbouring defined mutations in htrA, aroA or htrA aroA combined. When administered orally
or intravenously to BALB/c mice, all the mutants were found to be highly attenuated. All
mutants were able to confer significant protection against lethal challenge with SL1344 after
a single oral dose of live organisms. SL1344 htrA mutants persisted in livers and spleens at
a lower level than SL1344 aroA mutants after intravenous administration. SL1344 htrA aroA …
harbouring defined mutations in htrA, aroA or htrA aroA combined. When administered orally
or intravenously to BALB/c mice, all the mutants were found to be highly attenuated. All
mutants were able to confer significant protection against lethal challenge with SL1344 after
a single oral dose of live organisms. SL1344 htrA mutants persisted in livers and spleens at
a lower level than SL1344 aroA mutants after intravenous administration. SL1344 htrA aroA …