SB-207499
J Silvestre, A Graul, J Castaner - Drugs of the Future, 1998 - access.portico.org
[I] of PDE4 subtypes remains to be established, the differential cAMP modulation in different
cells implies the possibility of designing agents that are capable of acting selectively on one
or more of these PDE4 subtypes. In the search for new antiasthmatic and antiinflammatory
agents, scientists at SmithKline Beecham synthesized various second-generation
phosphodiesterase 4 inhibitors designed to maintain the potent antiinflammatory activity of
rolipram while presenting a more favorable adverse effect profile. As a result of these efforts …
cells implies the possibility of designing agents that are capable of acting selectively on one
or more of these PDE4 subtypes. In the search for new antiasthmatic and antiinflammatory
agents, scientists at SmithKline Beecham synthesized various second-generation
phosphodiesterase 4 inhibitors designed to maintain the potent antiinflammatory activity of
rolipram while presenting a more favorable adverse effect profile. As a result of these efforts …
