Regulation of pancreatic β-cell mass in vivo
S Bonner-Weir - Proceedings of the 1992 Laurentian Hormone …, 1994 - Elsevier
Publisher Summary Recently, it has been found that in transplanted islets, the amount of
functional β-cell mass changes, dependent on demand, with changes in replication and/or
cell size. In a study described in this chapter, isolated islets were transplanted under the
kidney capsule of diabetic or control mice. There were three groups, the first two having
been diabetic before transplantation:(1) animals that were transplanted with enough islets
(300) to return to normoglycemia,(2) animals transplanted with insufficient islets (150) to …
functional β-cell mass changes, dependent on demand, with changes in replication and/or
cell size. In a study described in this chapter, isolated islets were transplanted under the
kidney capsule of diabetic or control mice. There were three groups, the first two having
been diabetic before transplantation:(1) animals that were transplanted with enough islets
(300) to return to normoglycemia,(2) animals transplanted with insufficient islets (150) to …