Molecular and clinical correlations of deletions leading to Duchenne and Becker muscular dystrophies

LL Baumbach, JS Chamberlain, PA Ward, NJ Farwell… - Neurology, 1989 - AAN Enterprises
LL Baumbach, JS Chamberlain, PA Ward, NJ Farwell, CT Caskey
Neurology, 1989AAN Enterprises
Human DMD cDNA probes have been used to delineate possible deletions in 160 affected
males. Approximately 56% of these individuals had detectable deletions, 29% of which
mapped to a region centered around 500 kb from the 5'end of the gene whereas 69%
mapped to a region located centrally 1,200 kb from the 5'end. We have observed no
correlation between the extent of a deletion, its location, and clinical severity of the
associated disease. For some cases with deletions in the two high-frequency deletion …
Human DMD cDNA probes have been used to delineate possible deletions in 160 affected males. Approximately 56% of these individuals had detectable deletions, 29% of which mapped to a region centered around 500 kb from the 5' end of the gene whereas 69% mapped to a region located centrally 1,200 kb from the 5' end. We have observed no correlation between the extent of a deletion, its location, and clinical severity of the associated disease. For some cases with deletions in the two high-frequency deletion regions, the predicted effect upon translational reading frame of the resultant dystrophin mRNA did not correlate with the associated disease phenotype.
American Academy of Neurology