Transmissible spongiform encephalopathies, amyloidoses and yeast prions: common threads?
B Caughey - Nature medicine, 2000 - nature.com
Nature medicine, 2000•nature.com
Mammalian transmissible spongiform encephalopathy (prion) and amyloid diseases seem
to involve the self-propagation of abnormal fibrillar or sub-fibrillar protein aggregates. Similar
processes explain protein-mediated inheritance by yeast prions. Indeed, yeast prions are
more surely mediated solely by aberrant protein aggregates than are their mammalian
namesakes. Tantalizing parallels make yeast prions attractive models of mammalian protein-
folding diseases.
to involve the self-propagation of abnormal fibrillar or sub-fibrillar protein aggregates. Similar
processes explain protein-mediated inheritance by yeast prions. Indeed, yeast prions are
more surely mediated solely by aberrant protein aggregates than are their mammalian
namesakes. Tantalizing parallels make yeast prions attractive models of mammalian protein-
folding diseases.
Abstract
Mammalian transmissible spongiform encephalopathy (prion) and amyloid diseases seem to involve the self-propagation of abnormal fibrillar or sub-fibrillar protein aggregates. Similar processes explain protein-mediated inheritance by yeast prions. Indeed, yeast prions are more surely mediated solely by aberrant protein aggregates than are their mammalian namesakes. Tantalizing parallels make yeast prions attractive models of mammalian protein-folding diseases.
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