Molecular cloning and expression of a human heart inward rectifier potassium channel
KF Raab-Graham, CM Radeke, CA Vandenberg - Neuroreport, 1994 - journals.lww.com
WE have isolated a cDNA encoding an inwardly rectifying K+ channel (HH-IRK1) from
human heart. The cDNA codes for a 427-amino acid protein, with two putative
transmembrane domains and an H5 region. The primary structure of HH-IRK1 is
homologous to that of the IRK1 channel cloned from a mouse macrophage-like cell line.
Functional expression in Xenopus oocytes showed that HH-IRK1 is a K+ channel with strong
inward rectification, blocked by extracellular Ba 2+ and Cs+, and with a single-channel …
human heart. The cDNA codes for a 427-amino acid protein, with two putative
transmembrane domains and an H5 region. The primary structure of HH-IRK1 is
homologous to that of the IRK1 channel cloned from a mouse macrophage-like cell line.
Functional expression in Xenopus oocytes showed that HH-IRK1 is a K+ channel with strong
inward rectification, blocked by extracellular Ba 2+ and Cs+, and with a single-channel …