Transdifferentiation and metaplasia—switching cell types
JMW Slack, D Tosh - Current opinion in genetics & development, 2001 - Elsevier
JMW Slack, D Tosh
Current opinion in genetics & development, 2001•ElsevierStates of developmental commitment are encoded as combinations of transcription factors
and changes in their expression can bring about transdifferentiation or metaplasia. For
example, ectopic expressions of Vestigial can convert Drosophila leg to wing; of C/EBPβ can
convert pancreatic exocrine cells to hepatocytes; and expression of C/EBPα and PPARγ can
convert myoblasts to adipocytes.
and changes in their expression can bring about transdifferentiation or metaplasia. For
example, ectopic expressions of Vestigial can convert Drosophila leg to wing; of C/EBPβ can
convert pancreatic exocrine cells to hepatocytes; and expression of C/EBPα and PPARγ can
convert myoblasts to adipocytes.
States of developmental commitment are encoded as combinations of transcription factors and changes in their expression can bring about transdifferentiation or metaplasia. For example, ectopic expressions of Vestigial can convert Drosophila leg to wing; of C/EBPβ can convert pancreatic exocrine cells to hepatocytes; and expression of C/EBPα and PPARγ can convert myoblasts to adipocytes.
Elsevier