The cellular and molecular response of cardiac myocytes to mechanical stress
J Sadoshima, S Izumo - Annual review of physiology, 1997 - annualreviews.org
▪ Abstract External load plays a critical role in determining muscle mass and its phenotype in
cardiac myocytes. Cardiac myocytes have the ability to sense mechanical stretch and
convert it into intracellular growth signals, which lead to hypertrophy. Mechanical stretch of
cardiac myocytes in vitro causes activation of multiple second messenger systems that are
very similar to growth factor-induced cell signaling systems. Stretch of neonatal rat cardiac
myocytes stimulates a rapid secretion of angiotensin II which, together with other growth …
cardiac myocytes. Cardiac myocytes have the ability to sense mechanical stretch and
convert it into intracellular growth signals, which lead to hypertrophy. Mechanical stretch of
cardiac myocytes in vitro causes activation of multiple second messenger systems that are
very similar to growth factor-induced cell signaling systems. Stretch of neonatal rat cardiac
myocytes stimulates a rapid secretion of angiotensin II which, together with other growth …