Rab GTPases: specifying and deciphering organelle identity and function
SR Pfeffer - Trends in cell biology, 2001 - cell.com
Trends in cell biology, 2001•cell.com
Ten years ago, 20 Rab proteins had been identified as organelle-specific GTPases, and two
were known to be essential for vesicle targeting in yeast. Today, more than 60 mammalian
Rab proteins have been identified. While Rabs were always viewed as key regulatory
factors, no one could have anticipated their diversity of functions and multitude of effectors.
Rabs organize distinct protein scaffolds within a single organelle and act in a combinatorial
manner with their effectors to regulate all stages of membrane traffic.
were known to be essential for vesicle targeting in yeast. Today, more than 60 mammalian
Rab proteins have been identified. While Rabs were always viewed as key regulatory
factors, no one could have anticipated their diversity of functions and multitude of effectors.
Rabs organize distinct protein scaffolds within a single organelle and act in a combinatorial
manner with their effectors to regulate all stages of membrane traffic.
Abstract
Ten years ago, 20 Rab proteins had been identified as organelle-specific GTPases, and two were known to be essential for vesicle targeting in yeast. Today, more than 60 mammalian Rab proteins have been identified. While Rabs were always viewed as key regulatory factors, no one could have anticipated their diversity of functions and multitude of effectors. Rabs organize distinct protein scaffolds within a single organelle and act in a combinatorial manner with their effectors to regulate all stages of membrane traffic.
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