Rab proteins as membrane organizers

M Zerial, H McBride - Nature reviews Molecular cell biology, 2001 - nature.com
Nature reviews Molecular cell biology, 2001nature.com
Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial
distribution and communicate through an elaborate system of vesiculo-tubular transport.
Rab proteins and their effectors coordinate consecutive stages of transport, such as vesicle
formation, vesicle and organelle motility, and tethering of vesicles to their target
compartment. These molecules are highly compartmentalized in organelle membranes,
making them excellent candidates for determining transport specificity and organelle …
Abstract
Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial distribution and communicate through an elaborate system of vesiculo-tubular transport. Rab proteins and their effectors coordinate consecutive stages of transport, such as vesicle formation, vesicle and organelle motility, and tethering of vesicles to their target compartment. These molecules are highly compartmentalized in organelle membranes, making them excellent candidates for determining transport specificity and organelle identity.
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