Circuits and mechanisms governing hypothalamic responses to stress: a tale of two paradigms
PE Sawchenko, HY Li, A Ericsson - Progress in brain research, 2000 - Elsevier
Significant threats to homeostasis, be they real or perceived, and whether posed by events
in the outside world or from within, evoke adaptive responses that serve to defend the
stability of the internal environment. This commonly includes activation of:(1) the
neuroendocrine cascade of events whereby the pituitary, under hypothalamic control,
releases ACTH into the general circulation to stimulate production and release of
glucocorticoids from the adrenal cortex; and (2) the more purely neuronal mechanisms that …
in the outside world or from within, evoke adaptive responses that serve to defend the
stability of the internal environment. This commonly includes activation of:(1) the
neuroendocrine cascade of events whereby the pituitary, under hypothalamic control,
releases ACTH into the general circulation to stimulate production and release of
glucocorticoids from the adrenal cortex; and (2) the more purely neuronal mechanisms that …