High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines
T Calandra, J Gerain, D Heumann… - The American journal of …, 1991 - Elsevier
Abstract purpose and patients: We measured the serum concentrations of interleukin-6 (IL-6)
in 70 patients with established septic shock caused predominantly by gram-negative
bacteria. The aims of the study were to determine whether and for how long IL− 6 was
detectable in the circulation of these patients, to assess whether IL-6 levels were associated
with patients' outcomes, and, finally, to examine the interplay between IL-6, tumor necrosis
factor (TNF), interleukin-1β (IL-1β), and interferon-γ (IFN-γ). results: IL-6 was detected in …
in 70 patients with established septic shock caused predominantly by gram-negative
bacteria. The aims of the study were to determine whether and for how long IL− 6 was
detectable in the circulation of these patients, to assess whether IL-6 levels were associated
with patients' outcomes, and, finally, to examine the interplay between IL-6, tumor necrosis
factor (TNF), interleukin-1β (IL-1β), and interferon-γ (IFN-γ). results: IL-6 was detected in …