T-Independent immune response: new aspects of B cell biology
S Fagarasan, T Honjo - Science, 2000 - science.org
S Fagarasan, T Honjo
Science, 2000•science.orgRecent results emphasize the roles of T-independent antibody response in humoral
defenses, for which B1 cells and marginal zone B cells are mostly responsible. We discuss
how these cells are activated, migrate, and differentiate into antibody-producing cells in
various lymphoid tissues. Based on recent findings in each of these areas of B cell biology,
we propose a possible mechanism for peripheral tolerance of autoreactive B cells at target
organs.
defenses, for which B1 cells and marginal zone B cells are mostly responsible. We discuss
how these cells are activated, migrate, and differentiate into antibody-producing cells in
various lymphoid tissues. Based on recent findings in each of these areas of B cell biology,
we propose a possible mechanism for peripheral tolerance of autoreactive B cells at target
organs.
Recent results emphasize the roles of T-independent antibody response in humoral defenses, for which B1 cells and marginal zone B cells are mostly responsible. We discuss how these cells are activated, migrate, and differentiate into antibody-producing cells in various lymphoid tissues. Based on recent findings in each of these areas of B cell biology, we propose a possible mechanism for peripheral tolerance of autoreactive B cells at target organs.
AAAS