[HTML][HTML] Interleukin-10 receptor signaling through the JAK-STAT pathway: requirement for two distinct receptor-derived signals for anti-inflammatory action
JK Riley, K Takeda, S Akira, RD Schreiber - Journal of Biological Chemistry, 1999 - ASBMB
Interleukin-10 (IL-10) is a cytokine that has pleiotropic effects on a variety of different cell
types. Although many of the biologic responses induced by IL-10 are also induced by other
cytokines, such as IL-6, IL-10 is relatively unique in its ability to potently inhibit production of
pro-inflammatory cytokines in macrophages. In this study, we have used gain-of-function
and loss-of-function genetic approaches to define the intracellular components involved in
the different biologic actions of IL-10. Herein, we demonstrate that the ability of IL-10 to …
types. Although many of the biologic responses induced by IL-10 are also induced by other
cytokines, such as IL-6, IL-10 is relatively unique in its ability to potently inhibit production of
pro-inflammatory cytokines in macrophages. In this study, we have used gain-of-function
and loss-of-function genetic approaches to define the intracellular components involved in
the different biologic actions of IL-10. Herein, we demonstrate that the ability of IL-10 to …