[HTML][HTML] Pro-collagenase-1 (matrix metalloproteinase-1) binds the α2β1 integrin upon release from keratinocytes migrating on type I collagen
JA Dumin, SK Dickeson, TP Stricker… - Journal of Biological …, 2001 - ASBMB
In injured skin, collagenase-1 (matrix metalloproteinase-1 (MMP-1)) is induced in migrating
keratinocytes. This site-specific expression is regulated by binding of the α 2 β 1 integrin with
dermal type I collagen, and the catalytic activity of MMP-1 is required for keratinocyte
migration. Because of this functional association among substrate/ligand, receptor, and
proteinase, we assessed whether the integrin also directs the compartmentalization of MMP-
1 to its matrix target. Indeed, pro-MMP-1 co-localized to sites of α 2 β 1 contacts in migrating …
keratinocytes. This site-specific expression is regulated by binding of the α 2 β 1 integrin with
dermal type I collagen, and the catalytic activity of MMP-1 is required for keratinocyte
migration. Because of this functional association among substrate/ligand, receptor, and
proteinase, we assessed whether the integrin also directs the compartmentalization of MMP-
1 to its matrix target. Indeed, pro-MMP-1 co-localized to sites of α 2 β 1 contacts in migrating …