[HTML][HTML] The α-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction …
The α-chemokine stromal cell-derived factor (SDF)-1α binds to the seven transmembrane G-
protein-coupled CXCR-4 receptor and acts to modulate cell migration and proliferation. The
signaling pathways that mediate the effects of SDF-1α are not well characterized. We
studied events following SDF-1α binding to CXCR-4 in a model murine pre-B cell line
transfected with human CXCR-4. There was enhanced tyrosine phosphorylation and
association of components of focal adhesion complexes such as the related adhesion focal …
protein-coupled CXCR-4 receptor and acts to modulate cell migration and proliferation. The
signaling pathways that mediate the effects of SDF-1α are not well characterized. We
studied events following SDF-1α binding to CXCR-4 in a model murine pre-B cell line
transfected with human CXCR-4. There was enhanced tyrosine phosphorylation and
association of components of focal adhesion complexes such as the related adhesion focal …