The nephropathy of the nail-patella syndrome: clinicopathologic analysis of 11 kindred
WM Bennett, JE Musgrave, RA Campbell… - The American journal of …, 1973 - Elsevier
Seventy-two members of 11 kindred with the nail-patella syndrome were studied. Twelve
patients who had electron microscopic examinations of renal tissue had abnormalities of the
glomerular basement membrane. An unaffected family member did not. This lesion
consisted of irregular basement membrane thickening, epithelial foot process fusion and the
presence of fibrillar collagen-like material within the substance of the membrane. Many
patients also showed areas of increased lucency giving the membrane a “moth-eaten” …
patients who had electron microscopic examinations of renal tissue had abnormalities of the
glomerular basement membrane. An unaffected family member did not. This lesion
consisted of irregular basement membrane thickening, epithelial foot process fusion and the
presence of fibrillar collagen-like material within the substance of the membrane. Many
patients also showed areas of increased lucency giving the membrane a “moth-eaten” …