[HTML][HTML] Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene: involvement of the farnesoid X receptor/9-cis-retinoic acid …

J Grober, I Zaghini, H Fujii, SA Jones… - Journal of Biological …, 1999 - ASBMB
Intestinal bile acid-binding protein (I-BABP) is a cytosolic protein that binds bile acids (BAs)
with a high affinity. In the small intestine, its expression is restricted to the ileum where it is
involved in the enterohepatic circulation of BAs. Using the human enterocyte-like Caco-2
cell line, we have recently shown that BAs increased I-BABP gene expression. To determine
whether this regulation occurs in vivo, the effect of BA depletion or supplementation was
studied in mice. A dramatic drop in I-BABP mRNA levels was observed in mice treated with …