[HTML][HTML] Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor
BA Laffitte, HR Kast, CM Nguyen, AM Zavacki… - Journal of Biological …, 2000 - ASBMB
The farnesoid X-activated receptor (FXR; NR1H4) is a member of the nuclear hormone
receptor superfamily and functions as a heterodimer with the 9-cis-retinoic acid receptor
(RXR). In order to determine the optimal DNA binding sequence for the FXR/RXR
heterodimer, we have utilized the selectedand amplified binding sequence imprinting
technique. This technique identified a number of related sequences that interacted with
FXR/RXR in vitro. The consensus sequence contained an inverted repeat of the sequence …
receptor superfamily and functions as a heterodimer with the 9-cis-retinoic acid receptor
(RXR). In order to determine the optimal DNA binding sequence for the FXR/RXR
heterodimer, we have utilized the selectedand amplified binding sequence imprinting
technique. This technique identified a number of related sequences that interacted with
FXR/RXR in vitro. The consensus sequence contained an inverted repeat of the sequence …