Characterization of a specific ligand for P-selectin on myeloid cells. A minor glycoprotein with sialylated O-linked oligosaccharides

KE Norgard, KL Moore, S Diaz, NL Stults… - Journal of Biological …, 1993 - ASBMB
Lectin-carbohydrate recognition between the selectins and their ligands are among the
earliest events in leukocyte recirculation, leukocyte recruitment into inflamed areas, and
abnormal egress of leukocytes in diseases. Previously, we have described a dimeric
sialoglycoprotein from myeloid cells with subunits of molecular mass= 120 kDa, which is
selectively recognized by P-selectin (Moore, KL, Stults, NL, Diaz, S., Smith, DF, Cummings,
RD, Varki, A., and McEver, RP (1992) J. Cell Biol. 188, 445-456). Here, we demonstrate that …