Modulating chemokines: more lessons from viruses
AS Lalani, JW Barrett, G McFadden - Immunology today, 2000 - cell.com
AS Lalani, JW Barrett, G McFadden
Immunology today, 2000•cell.comChemokines are crucial effector molecules involved in orchestrating the host inflammatory
response against invading pathogens. Viruses have devised several strategies for exploiting
or neutralizing chemokines or their receptors to further their own propagation or elude host
defenses. Insight into strategies used by viruses to modulate chemokines might help
generate novel approaches for treating viral diseases and chemokine-mediated
inflammatory disorders.
response against invading pathogens. Viruses have devised several strategies for exploiting
or neutralizing chemokines or their receptors to further their own propagation or elude host
defenses. Insight into strategies used by viruses to modulate chemokines might help
generate novel approaches for treating viral diseases and chemokine-mediated
inflammatory disorders.
Abstract
Chemokines are crucial effector molecules involved in orchestrating the host inflammatory response against invading pathogens. Viruses have devised several strategies for exploiting or neutralizing chemokines or their receptors to further their own propagation or elude host defenses. Insight into strategies used by viruses to modulate chemokines might help generate novel approaches for treating viral diseases and chemokine-mediated inflammatory disorders.
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