Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesis
SH Speck, HW Virgin IV - Current opinion in microbiology, 1999 - Elsevier
SH Speck, HW Virgin IV
Current opinion in microbiology, 1999•ElsevierA general association of human and primate lymphotropic herpesviruses (γ-herpesviruses)
with the development of lymphomas, as well as other tumors, especially in
immunocompromised hosts, has been well documented. The lack of relevant small animal
models for human γ-herpesviruses has impeded progress in understanding the role of these
viruses in the development of chronic disease. Recent research characterizing infection of
inbred strains of mice with a murine γ-herpesvirus, gamma-herpesvirus 68 (γHV68), is …
with the development of lymphomas, as well as other tumors, especially in
immunocompromised hosts, has been well documented. The lack of relevant small animal
models for human γ-herpesviruses has impeded progress in understanding the role of these
viruses in the development of chronic disease. Recent research characterizing infection of
inbred strains of mice with a murine γ-herpesvirus, gamma-herpesvirus 68 (γHV68), is …
A general association of human and primate lymphotropic herpesviruses (γ-herpesviruses) with the development of lymphomas, as well as other tumors, especially in immunocompromised hosts, has been well documented. The lack of relevant small animal models for human γ-herpesviruses has impeded progress in understanding the role of these viruses in the development of chronic disease. Recent research characterizing infection of inbred strains of mice with a murine γ-herpesvirus, gamma-herpesvirus 68 (γHV68), is providing insights into viral and host factors involved in the establishment and control of chronic γ-herpesvirus infection.
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