[HTML][HTML] Constitutive activation of c-Met in liver metastatic B16 melanoma cells depends on both substrate adhesion and cell density and is regulated by a cytosolic …
D Rusciano, P Lorenzoni, MM Burger - Journal of Biological Chemistry, 1996 - ASBMB
Serial selection in vivo for liver colonization of B16 murine melanoma cells consistently
resulted in cell lines expressing elevated amounts of the hepatocyte growth factor/scatter
factor receptor (c-Met), which is constitutively activated in the absence of its cognate ligand.
In this paper we present evidence suggesting that c-Met constitutive activation in liver-
specific B16 melanoma cells depends on both receptor concentration on the cell surface
and a cytosolic tyrosine phosphatase activity. In fact, c-Met constitutive activation is suddenly …
resulted in cell lines expressing elevated amounts of the hepatocyte growth factor/scatter
factor receptor (c-Met), which is constitutively activated in the absence of its cognate ligand.
In this paper we present evidence suggesting that c-Met constitutive activation in liver-
specific B16 melanoma cells depends on both receptor concentration on the cell surface
and a cytosolic tyrosine phosphatase activity. In fact, c-Met constitutive activation is suddenly …
