[HTML][HTML] Transcriptional activation of the glucose transporter GLUT1 in ventricular cardiac myocytes by hypertrophic agonists

C Montessuit, A Thorburn - Journal of Biological Chemistry, 1999 - ASBMB
Myocardial hypertrophy is associated with increased basal glucose metabolism. Basal
glucose transport into cardiac myocytes is mediated by the GLUT1 isoform of glucose
transporters, whereas the GLUT4 isoform is responsible for regulatable glucose transport.
Treatment of neonatal cardiac myocytes with the hypertrophic agonist 12-O-
tetradecanoylphorbol-13-acetate or phenylephrine increased expression of Glut1 mRNA
relative to Glut4 mRNA. To study the transcriptional regulation of GLUT1 expression …