GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines.
AC McPherron, SJ Lee - Journal of Biological Chemistry, 1993 - ASBMB
Two new mammalian members (growth/differentiation factor 3 (GDF-3) and GDF-9) of the
transforming growth factor-beta superfamily were identified using degenerate
oligonucleotides corresponding to conserved regions among known family members. By
Northern analysis, GDF-3 transcripts were detected primarily in adult bone marrow, spleen,
thymus, and adipose tissue. In contrast, GDF-9 transcripts were detected only in the ovary.
Based on their cDNA sequences, the predicted GDF-3 and GDF-9 polypeptides each …
transforming growth factor-beta superfamily were identified using degenerate
oligonucleotides corresponding to conserved regions among known family members. By
Northern analysis, GDF-3 transcripts were detected primarily in adult bone marrow, spleen,
thymus, and adipose tissue. In contrast, GDF-9 transcripts were detected only in the ovary.
Based on their cDNA sequences, the predicted GDF-3 and GDF-9 polypeptides each …